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Elevated D-dimer levels may reflect multifactorial interactions between carcinoma growth and the hemostatic-fibrinolytic system in malignancy.
Also, several psychiatric and neurologic disorders are the result of multifactorial interactions between environmental influences and genetic mechanisms.
Dental anomalies are caused by complex multifactorial interactions between genetic, epigenetic and environmental factors during the long process of dental development.
Although the exact pathogenesis of SLE remains elusive, extremely complicated and multifactorial interactions between genetic and environmental factors are thought to contribute to the development of the disease [ 2].
Because of the multifactorial interactions between brain injury, temperature control, cerebral blood flow, and autoregulation, the answer to all questions is impossible within an observational study design based on a limited number of cases.
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We note that there is support in the literature for complex and multifactorial interaction between ZA and hormones both within and outside the bone environment.
Because of the multifactorial interactions involved in this complex system, a simple deterministic explanation for the interannual correlation between El Niño and VL is not possible.
The pathogenesis of COPD was affected by the multifactorial interactions of both environmental triggers and genetic susceptibility [ 2, 3].
Plasminogen activation depends on a multifactorial interaction with the bacterial surface.
The exact etiology of SLE is still unclear, although multifactorial interaction with genetic and environmental factors has been implicated.
Such studies demonstrate how the natural history of complex human diseases and their responsiveness to treatment are multifactorial phenomena, affected by interactions between genetically determined characteristics of each person, which in turn affect the person's interaction with environmental factors.
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