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In synthesis, complex segregation analysis suggests a multifactorial inheritance for migraine with and without aura and chronic tension-type headache [28].
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A classical segregation analysis analyses for Mendelian inheritance, while a complex segregation analysis also analyses for multifactorial inheritance, as well as transmissible and non transmissible environmental factors [23].
For those without an identifiable etiology, counseling should be provided for multifactorial inheritance.
Although no specific chromosomal abnormality for microtia has been cited, a multifactorial inheritance has been suggested, especially for syndromes such as Franceschetti syndrome or Goldenhar syndrome.
Multifactorial inheritance is the most important model accounting for the genetic behavior of the common epilepsies.
Collectively, our results demonstrate the high-throughput generation of gene knock-in cell collections, which can contribute not only to the production of multiplexed reporter cells, but also to the simultaneous generation and evaluation of multiple polymorphisms spanning several gene loci for analyzing phenotypic variations or disease severity caused by multifactorial inheritance.
Familial colorectal cancer remains undefined and is presumably due to multifactorial inheritance.
Genetic and allelic heterogeneity, multifactorial inheritance, and low penetrance of susceptibility alleles substantially complicate both study design and interpretation of results.
Most primary headaches have multifactorial inheritance and a precise description of the pathogenesis is lacking.
It is expected that identification of genetic markers will be difficult due to multifactorial inheritance.
Migraine has a strong (up to 50%) genetic component with a probable multifactorial inheritance [5].
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