Although the underlying mechanisms contributing to neurodegeneration in PD seem to be multifactorial, mitochondrial impairment and oxidative stress are widely considered to be central to many forms of the disease.
The etiology of insulin resistance within skeletal muscle in the human with type 2 diabetes is multifactorial, involving impairments in hormonal signaling, enzyme and transporter activity, and substrate availability.
In this respect, the multifactorial aspects of cognitive impairment may be incorporated into the dynamic polygon hypothesis, which takes into account the contribution of strokes of all sizes, as well as white matter hyperintensities, in parallel to those of plaques and tangles [12].
Early epidemiological data suggest a multifactorial etiology to cognitive impairment in the cART era.
Although many cases of language impairment are multifactorial, mutations in a single gene on 7q31, FOXP2, have been shown to cause developmental verbal dyspraxia in a large pedigree, called the KE family (Lai et al. 2000, 2001), and a number of individual cases [reviewed in Fisher and Scharff (2009)].
71 72 Functional anaerobic training has been included in this study to address the multifactorial nature of motor impairments seen in CP, as well as incorporating context-specific training relatable to the outcomes being assessed (eg, anaerobic power and mobility).
This increase of systemic fungal infections recognizes a multifactorial origin, including host defense impairment and type of underlying disease.
Hearing impairment is a multifactorial disorder, caused by both genetic and environmental factors, including noise and ototoxic drugs, such as aminoglycoside antibiotics.
As discussed above, patients with Parkinson's disease and PDD exhibit deficits in each of these latter processes, which means that apparent memory impairments have a multifactorial basis here.
Ball et al. [8] pointed out that the brain regions most frequently involved in herpes encephalitis are also the earliest and most severely involved targets of the neurodegenerative alterations of Alzheimer's disease (AD), a multifactorial disorder characterized by severe memory impairment and cognitive decline [9].
