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Finding genes predisposing to more common, multifactorial forms of type 2 diabetes represents a far greater challenge, and only a handful of robust, well-replicated examples have been established.
Genes previously implicated in monogenic and multifactorial forms of diabetes are obvious candidates in this respect.
Growing evidence of overlap in the genes involved in monogenic and multifactorial forms of diabetes [ 6] made this an excellent proposition.
After the first set of single gene diabetes types was described in the 1990s, some researchers postulated that the possible involvement of these genes in common multifactorial forms of the disease should be tested.
Similar(56)
We may speculate that this family presents a polygenic multifactorial form of migraine; it is known that given the right environmental context, some individuals can develop motor aura despite not having a specific FHM genotype.
We propose a polygenic or multifactorial form of inheritance in the undiagnosed group, whereby affected genes in combination with other adverse genetic and/or environmental factors may exceed a critical threshold for phenotypic manifestation.
The diagnosis of ADH is difficult, due to the overlap of cholesterol values between monogenic and multifactorial forms.
Over the multifactorial form, it is important to remark the existence of Glaucomas which are characterized by Mendelian inheritance (mainly autosomal-recessive and autosomal-dominant).
Nevertheless, other forms of congenital hydrocephalus are mostly multifactorial with a recurrence risk of about 4% [39].
44 However, this multifactorial type of injury would logically require variable forms of treatment beyond simply treatment of the muscle tendon injuries.
Coronary artery disease (CAD) is a complex multifactorial and polygenic disorder resulting from an excessive inflammatory response to various forms of injurious stimuli to the arterial wall [ 1– 3].
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