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Braak et al. (2003) observed the multifactorial features and complexity of disease progression based on α-syn pathology in PD patients' brains, and suggested that pathology may start in the olfactory nucleus and several dorsal motor nuclei and in time progress as α-syn pathology spreads upwards into midbrain and cortex.
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The difficulty of finding a common genetic pattern of association is caused by the multifactorial feature of the disease that shows different characterizations by world region and race.
While obesity is a multifactorial feature, studies on twin and adopted children susceptibility to fat accumulation demonstrate that genetic predisposition is a key contributing factor in obesity [ 4- 9].
The pathophysiology of SAE is multifactorial and features cerebrovascular endothelial dysfunction, blood-brain barrier disruption and abnormal neurotransmitter patterns.
We then used GeneNetWeaver's multifactorial perturbation feature to generate expression data with these perturbations.
Given the wide range of features, multifactorial computational approaches are still scarce and unable to predict all the characteristics described above in silico.
In multifactorial analysis, the independent features were a lack of tubule formation and pushing tumour margins only.
Revised multifactorial analysis incorporating tumour features did not strongly support a high risk for either R1699Q or A1708V, with posterior probabilities perhaps suggestive of a moderately increased risk.
The mechanism for hypoxic influence of these features is likely multifactorial, however there is clear interplay with EMT.
Although the exact details concerning the cause of compaction remain unknown, some features of the multifactorial process are understood.
The presented method, with its user-friendly web application, simplifies the use of co-segregation as one of the key features in a multifactorial approach considerably.
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CEO of Professional Science Editing for Scientists @ prosciediting.com