The mechanism of this synergistic apoptotic effect on MM cells is multifactorial and includes disruption of protein degradation and inhibition of the interaction of MM cells with the tumor microenvironment [ 217].
Subsequently, the deterioration of cognitive function to PD-MCI is associated with an extension from frontal regions to a wider involvement of posterior temporal cortices, most probably as a result of its multifactorial nature in conjunction with generalized disruptions of other neurotransmitter systems.
The causes of sleep disruption in the ICU are multifactorial.
The reasons for this are multifactorial and well described; they include the disruption of feedback loops, development of crosstalk and other escape mechanisms observed with signalling pathway inhibitors, as well as other issues such as intratumoural heterogeneity.
Analysis of our cases indicates that amniotic band syndrome may not primarily be the consequence of amniotic or vascular disruption but rather the result of multifactorial processes responsible for the developmental malformations and fetal ecto-mesodermal disruption leading to amniotic rupture and vascular compromise.
The pathophysiology of SAE is multifactorial and features cerebrovascular endothelial dysfunction, blood-brain barrier disruption and abnormal neurotransmitter patterns.
The frailty shows complex and multifactorial etiology, which includes interaction among neuromuscular disorders, endocrine disruption, and immune system dysfunction.
In horses, OC(D) is considered as a multifactorial disease and has been described as a focal disruption of endochondral ossification leading to the development of osteoarticular lesions.
Together, data show that epiboly and gastrulation defects induced by ethanol are multifactorial, and include yolk cell (extraembryonic tissue) microtubule cytoskeleton disruption and blastomere adhesion defects, in part caused by reduced pcdh18a expression.
Traits that are strongly influenced by mitochondrial translation and function (OXPHOS complex activity, Fig. 5) display distinct patterns of disruption corresponding to the simw – Aatm interaction, whereas multifactorial traits with less direct biochemical dependence on mitochondria (climbing, Fig. 2) show mild or no disruption.
