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OA is a multifactorial disorder that can be divided in non-genetic (age, gender, obesity, mechanical stress, inactive lifestyle, joint trauma, patient occupational activities) and genetic (altered gene expression patterns of the cartilage and subchondral bone) factors.
Glioblastoma is a complex multifactorial disorder that has swift and devastating consequences.
Coronary artery disease (CAD) is a multifactorial disorder that results from an excessive inflammatory response.
SLI is a prototypical multifactorial disorder that is predicted to involve numerous genetic loci and environmental factors.
T2DM is a complex multifactorial disorder that is characterized by insulin resistance and impaired β-cell functions.
Age-related hearing impairment (ARHI) is a complex, multifactorial disorder that is attributable to confounding intrinsic and extrinsic factors.
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SDB and OSAS are multifactorial disorders that are managed by various specialties such as pediatrics, otorhinolaryngology, neurology, oral medicine, orthodontics, sleep medicine, and oral and maxillofacial surgery.
Both depression and anxiety are multifactorial disorders that involve different brain processes and neural substrates.
Although at first appearance these disorders have different phenotypes, they all are heterogeneous, multifactorial disorders that share molecular mechanisms which elicit similar clinical and pathogenic features.
On the other hand, there is compelling evidence that CVD is a complex and multifactorial disorder and that its pathogenesis involves multiple molecules.
This approach assumes that the differences between the effects of the individual variants can be ignored, which may be a realistic assumption for multifactorial disorders given that the effect sizes are generally small [ 24].
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