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Complex or multifactorial diseases often have several genetic components as well as several behavioral components.
Complex polygenic and multifactorial diseases remain a challenge for human geneticists.
They are some multifactorial diseases and most of which may be primarily associated with atherosclerotic lesions.
Age is a recognized risk factor, contributing to the occurrence of multifactorial diseases.
Further work needs to be done to examine direct transcriptional activation of FRα responsive genes by FRα and its' role in these multifactorial diseases.
However, for multifactorial diseases such as colorectal cancer, breast and ovarian cancer, and Alzheimer disease (AD), genetic testing is less determinative and more "predispositional" in nature.
Here we aim to remind basic definitions of multifactorial diseases and the genetic related concepts underlying classical methods.
Designing drug candidates exhibiting polypharmacology is one of the strategies adopted by medicinal chemists to address multifactorial diseases.
Many research articles disclosing the development of such compounds for treatment of multifactorial diseases are published during last 7 years.
These are capable of eliciting multiple pharmacological actions and have emerged as magic bullets in treatment of multifactorial diseases.
Genome mapping has previously been used with success to identify the genes involved in the development of both monogenic and multifactorial diseases.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com