This is even more true in the context of multifactorial diseases, for not only are multiple genetic variants, each with their own effect sizes, involved in the causation of multifactorial diseases, there are also environmental factors at play.
Therefore, in contrast to that of clinical genetic testing for monogenic diseases, the clinical validity of genetic profiling for multifactorial diseases for the purposes of individual disease risk prediction, so far, has remained rather limited.
Thus, hESC and iPSC that carry a particular disease represent promising new disease models, especially for those single gene or multifactorial diseases for which no good animal models exist.
From the second position it follows that the need for face-to-face counseling does not apply to present-day personal genome testing for multifactorial diseases, for serious psychological impact is not to be expected (see section III, 2).
Preeclampsia is a multifactorial disease of pregnancy.
It is, however, expected that issues concerning, for example, diabetes risk worry and discrimination, might be less applicable for multifactorial diseases than for monogenic disorders [ 12], because of the preventive options that are available.
74, 75 A stochastic (i.e., nondeterministic) component has seldom been taken into account as a relevant actor in the pathogenesis of a multifactorial disease like MS. For some reason, our logical explorations tend to feel more comfortable in the presence of identifiable causes and effects.
Mitochondrial dysfunction is usually considered as one of many risk factors in multifactorial disease, as it predisposes for disease throughout the entire system.
Typically, genome-wide approaches generate large sets of potential genetic associations for further analysis; for example, multifactorial disease loci identified by linkage analysis can be approximately 30 Mb in size and contain several hundred genes [ 9].
