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Generative models focused on multifactorial causal mechanisms in brain disorders are scarce and generally based on limited data.
Here, we propose a spatiotemporal multifactorial causal model (MCM) of brain (dis)organization and therapeutic intervention that accounts for local causal interactions, effects propagation via physical brain networks, cognitive alterations, and identification of optimum therapeutic interventions.
Furthermore, using theoretical control analysis of the identified population-based multifactorial causal network, we show the crucial advantage of using combinatorial over single-target treatments, explain why one-target Aβ based therapies might fail to improve clinical outcomes, and propose an efficiency ranking of possible LOAD interventions.
The vast majority of participants endorsed multifactorial causal beliefs about common health conditions (see Table 2).
Yet, the extent to which the general public holds such multifactorial causal beliefs is unknown.
It examines several aspects of the public's multifactorial causal beliefs, which are defined as the simultaneous endorsement of both genetic and behavioral risk factors for health conditions.
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The data obtained from well-designed molecular and clinical studies support a multifactorial, systemic, nonatherosclerotic causal hypothesis, such as a defect in vascular structural proteins, with atherosclerosis occurring as a secondary process.
Pathophysiology of ADHD is multifactorial and its causal mechanisms have not precisely been established.
However, in most cases, diarrhoea is supposed to be multifactorial, without any identified causal factor [ 7].
Although past work has investigated aspects of either genetic or behavioral causal beliefs, multifactorial beliefs have not been evaluated systematically.
As periodontitis is a complex multifactorial disease, a plethora of causal factors determine the host response to the microbial challenge, including genetic, epigenetic, environmental and behavioural factors.
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