Meta-study is a multifaceted, systematical knowledge synthesis method aimed at better understanding how people construct knowledge.
The regulation of muscle protein synthesis is multifaceted and recent investigations have demonstrated such signalling pathways as Akt-mTOR and mitogen-activated protein kinase (MAPKs; e.g., Erk1/2) cascades as important promoters of exercise-induced anabolism [6], [12], [13], [14], [15], [16].
The validation activities are multifaceted and begin with the GMP synthesis and structural elucidation of the fluorescent peptides to be used for imaging studies.
SEA-ORCHID, a five-year project, is evaluating whether a multifaceted intervention to strengthen capacity for research synthesis, evidence-based care and knowledge implementation improves adoption of best clinical practice recommendations and so leads to better health for mothers and babies [5].
SEA-ORCHID (South East Asia Optimising Reproductive and Child Health In Developing countries) is evaluating whether a multifaceted intervention to strengthen capacity for research synthesis, evidence-based care and knowledge implementation improves adoption of best clinical practice recommendations leading to better health for mothers and babies.
At nine hospitals in Thailand, Malaysia, the Philippines and Indonesia, SEA-ORCHID investigated whether the health of mothers and babies can be improved through a multifaceted intervention to strengthen capacity for research synthesis, evidence-based care and knowledge implementation.
These studies suggest a far more expansive role for the ER in transcriptome expression, where membrane and secretory protein synthesis represents one element of a multifaceted and dynamic contribution to post-transcriptional gene expression.
South East Asia - Optimising Reproductive and Child Health in Developing Countries (SEA-ORCHID) was a five-year project that aimed to determine whether a multifaceted intervention designed to strengthen the capacity for research synthesis, evidence-based care and knowledge implementation improved clinical practice and led to better health outcomes for mothers and babies.
6 Thematic synthesis does provide an insight into the potential multifaceted and complex transformations that children and adolescents can encounter.
Thanks go to Moyen and colleagues for their insightful synthesis and for promoting ongoing discussion of this multifaceted, challenging and fundamental aspect of the practice of critical care medicine.
Overall, these multifaceted effects by changes in ECM, including dysregulation of matrix synthesis (reduction in collagen type II and aggrecan, increase in collagen type I and X), upregulation of matrix degradation, and induction of cell apoptosis, promote the progression of OA by altering the cellular behaviors of chondrocytes.
