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The results are consistent with a significant but multifaceted role for genetic factors influencing mate selection in humans.
This multifaceted role for hda-1 in C. elegans appears to be conserved in C. briggsae because Cbr-hda-1 :: gfp is expressed in a similar manner.
These studies increased our understanding of the characteristics of Tregs and highlighted a multifaceted role for Tregs in promoting cancer growth through both tumor immune escape and angiogenesis.
Collectively, our findings suggest a multifaceted role for CSB not only in neurogenesis but also in protecting the functional integrity of neural progenitor cells under low oxygen tension through transcriptional activation of factors involved in hypoxia signaling pathway.
Current indications predict a multifaceted role for miRNAs in plant innate immune responses, from pathogen recognition to modulating hormone responses and coordinating expression of defense genes [ 9, 10, 27].
Intriguingly, and indicative of a multifaceted role for the TRAIL DRs in CMV defense, myeloid cells from TRAIL-R2−/− mice produce increased levels of inflammatory cytokines when infected with mouse CMV (MCMV), promoting increased NK cell activation and enhanced control of viral replication in the spleen, but not the liver (Diehl et al., 2004).
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Multifaceted roles for miRNAs as molecular regulators during plant immune – and defense responses have been proposed [ 10, 27].
UNC-6/netrin first gained prominence as an axon guidance molecule [ 5, 6]; additional studies have revealed multifaceted roles for this guidance system, including in cell migration [ 5] and in glia-mediated coordination of synapse formation [ 7]. Park et al. [ 1] now show that UNC-6/netrin also acts as a direct signal for synaptic partner choice.
We provide evidence for a multifaceted role of the sensory system in regulating this decision.
The multifaceted role of Nek2 within the cell makes it an attractive target for therapeutic design and warrants further research to fully elucidate its mechanisms of action.
The recognition of CD44 as a receptor for a major microbial pathogen adds a new dimension to the multifaceted role of CD44 in cell-cell communication.
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