Very recently, several lines of evidence suggested that EMT is closely associated with acquisition of CSC phenotypes and resistance to anticancer agents, indicating that EMT is a complex cellular program driving to the multifaceted cancer progression.
5 Beyond metastasis, many studies also suggested that EMT is associated with other malignant phenotypes of cancer cells such as resistance to cancer therapies and the maintenance of cancer stem cells, indicating that EMT is a complex cellular program driving to the multifaceted cancer progression.
In this study, it was found that hepatocyte expression of Snail has a multifaceted effect on the progression of liver fibrosis through regulation of growth factor expression and ECM synthesis, which impacts hepatocytes themselves and other cell types.
Thus, DEC1 has multifaceted roles in cancer progression.
The tumour stroma contains CAFs (cancer-activated fibroblasts), similar to the transformed fibroblasts observed in wound healing and fibrosis [ 16], that play a multifaceted role in tumour progression.
β1-integrins are critical mediators of normal cell-ECM interactions and have been shown to play a multifaceted role in malignant progression [ 7].
However, the very recent data by Rolny et al (2008) suggest a reconsideration of this semaphorin as a multifaceted regulator of cancer progression: SEMA3B inhibited tumour growth in mice but simultaneously and unexpectedly triggered metastasis by activating the signalling kinase p38.
Analysis of the recent literature indicates the existence of multifaceted astroglial reactions in the progression of various neurodegenerative processes.
To the best of our knowledge, our present findings are the first report providing a new insight into a putative mechanism by which TSG101 bidirectionally participates in carcinogenesis and tumor progression as a multifaceted gene in different cell types.
ANXA1 expression is "tumor-specific" and might play a multifaceted role in cancer development and progression.
