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In considering how PLC activity may relate to migraine and its comorbidities, many of these distinct conditions share a multifaceted pathophysiology, with alterations in molecules as diverse as serotonin, adrenaline, estrogen, cannabinoids, and glutamate, and include the activation of several GPCRs, protein kinase mediated signaling, and early gene activation (c-fos) [36, 37].
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High symptom and societal burden justify intensive research for new evidence based effective pharmacotherapies for this self-limiting disease with multifaceted pathophysiology.
Depression is thought to have multifaceted pathophysiology and increased risk for having depression is related to type two diabetes and other cardiometabolic disorders [ 1– 3].
Some groups are multifaceted with communication interspersed with activities like relaxation, physical activity, weighing or physiological monitoring.
Mr. Elkins's multifaceted way with popular dancing is another of his singular gifts.
"Increasing the level of broadband adoption is a complex, multifaceted challenge with no simple, one-size-fits-all solution".
This is a multifaceted problem with deep historical roots, and we are doing too little about many of its causes.
Data have a multifaceted relationship with Grid infrastructure.
Orthodontically induced root resorption is a multifaceted phenomenon with complex etiopathology.
"These art centers are huge, multifaceted businesses with real estate, restaurant and retail components.
Whereas the Apple Watch is a more multifaceted device, with fitness features as part of a more fashion/lifestyle-focused proposition.
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