Sentence examples for multifaceted pathogenesis from inspiring English sources

The multifaceted pathogenesis of multiple sclerosis (MS) involves complex interactions between the immune and the central nervous systems which provide a multitude of targets for therapeutic interventions.

Further studies and animal models should help to further elucidate the pathological relevance of NGF/BDNF balance, as well as uncover the precise mechanism of this interaction in the multifaceted pathogenesis of SSc.

Clinical diversity in systemic sclerosis (SSc) reflects multifaceted pathogenesis and the effect of key growth factors or cytokines operating within a disease-specific microenvironment.

The dynamics of virus pathogenesis are multifaceted and can be better comprehended by looking at the system as a whole.

Our work suggests that TDP-43-regulated miRNAs may play multifaceted roles in the pathogenesis of cancer.

These findings suggest the possibility that MtaR may play a multifaceted role in GBS pathogenesis by regulating the expression of numerous genes.

Their complex etiology is common amongst the majority of neurodegenerative diseases; they are not monogenic or polygenic diseases and pathogenesis is multifaceted by events that are, most often, independent of genetic mutations.

Thus, our finding that Nef also utilizes TAK1 to activate and drive anti-inflammatory M2-M Φ towards an inflammatory M1-like phenotypic differentiation further strengthens the assertion that TAK1 have a multifaceted role in the pathogenesis of HIV-1.

The pathogenesis of sarcopenia is multifaceted and encompasses lifestyle habits, systemic factors (e.g., chronic inflammation and hormonal alterations), local environment perturbations (e.g., vascular dysfunction), and intramuscular specific processes.

In the first 24 hours after AKI was diagnosed, the variables including demographic data, presence of sepsis, need for mechanical ventilation, AKI pathogenesis (ischemic, nephrotoxic or multifaceted), comorbidity conditions, primary and concomitant diagnoses were recorded.

Based on the central role of autoantibodies and the multifaceted involvement of B cells in lupus pathogenesis, rituximab appeared as a potentially effective therapeutic agent in this setting.