The response of seronegative rheumatoid arthritis patients, even though less impressive, is indicative of the multifaceted implication of B-cells in the pathogenesis of the disease (e.g., generation of immune complexes that act as decoys to attract monocyte/macrophages and thus reduce their inflammatory activity in certain autoantibody-mediated processes) [ 27, 28].
We recommend this manuscript to be indexed, since it compiles and reviews the current scientific understanding of the South Asian nutrition transition, along with addressing the various associated factors and the multifaceted policy implications.
35 More so, evidence that statins also exert immunomodulatory effects, along with suggestions they may prove useful in the treatment and prevention of infections, 36 indicate they may have important, multifaceted clinical implications in populations such as Soweto, especially given the substantial dyslipidaemic risk associated with highly prevalent HIV infection and ART.
BRCA1 is a multifaceted tumor suppressor protein that has implications in processes such as cell cycle, transcription, DNA damage response and chromatin remodeling.
UNICEF's vision of promoting children's rights and creating a protective environment for all children is in fact a multifaceted program strategy with many practical implications for implementation – be it for the normative and legislative environment, for service delivery or at the community level.
The implications of this body of work are multifaceted and include the observation that small increases in average global temperatures may have measurable effects on performance in amphibian embryos and larvae.
The implications are that the benefits of R&R2ADHD are multifaceted and that combined psychopharmacological and CBT based treatments may add to and improve pharmacological interventions.
Implications and future directions This study uncovers a multifaceted requirement of RSK2 for regulation of synaptic function and MAPK-dependent processes in neurons.
DNA methylation is a multifaceted process with context dependent functions in genome regulation and wide-ranging clinical implications [ 40, 41].
