Given the importance of endothelial function as an independent risk factor for CVD [ 2, 3] we view our findings as a relevant demonstration of what a multifaceted exercise- and diet-based weight loss intervention can do to alleviate CVD risk.
The QRA world encompasses a multifaceted series of exercises, which present a different degree of complexity and difficulty.
In addition, guidelines for the optimal programming of such exercises in a multifaceted injury prevention programme should be investigated.
Network meta-analysis is particularly relevant to this, given that exercise is a complex and multifaceted intervention and the number of trials comparing the same exercise interventions is small.
20 Tinetti et al reported a prospective trial looking at exercise as part of a multifaceted approach to reducing falls, including adjustment to medications and behavioral instruction.
However, all interventions that were mentioned by more than one of the groups in the post-hoc focus group exercise were included in our multifaceted intervention.
35 Only recently has it been recognized that patients with CHF are prone to develop ID irrespective of anaemia, and ID has multifaceted clinical consequences related to poor outcome, exercise intolerance, and impaired quality of life.
The findings of our Cochrane review, based on 42 trials with over 8,000 patients, suggested using a multifaceted programme combining educational and behavioural strategies to enhance exercise adherence, and incorporating individualisation of the exercise, follow-up and supervision to improve exercise adherence [ 26].
To develop and pilot the multifaceted podiatry intervention including a foot and ankle exercise programme, supplementary DVD and booklet with approximately 60 participants.
Similarly, weight loss interventions among non-pregnant adults [ 15- 17] have shown that multifaceted interventions compared with stand-alone dietary advice, exercise modification, or behavioral strategies yield significant improvements in health outcomes and weight loss.
