We demonstrated that the beneficial effects observed after stem cell transplantation arise from multiple events that counteract multiple aspects of the disease; this feature is crucial for multifaceted disease such as ALS.
We now report on how a multi-targeted pharmacological approach needed for a complex multifaceted disease, such as aging, might take advantage of EVOO-derived polyphenols, pleiotropically impacting a wide variety of biological processes.
A multi-targeted pharmacological approach necessary for addressing a complex multifaceted disease such as aging might take advantage of pleiotropic natural polyphenols affecting a wide range of biological processes.
In summary, rsFC with PCC provides a useful tool for studying multifaceted neuropsychiatric diseases such as addiction at systems-level of assessment.
Because the causes of chronic diseases, such as CVD are complex, treatment should be multifaceted, integrated, and tailored to patient needs.
Care for patients with chronic diseases such as asthma, hypertension, and diabetes is challenging and requires multifaceted interventions in order to appropriately coordinate the entire treatment process [ 1].
In the lung, these pathways play a multifaceted role; their activation is critical for lung development, while their deregulation can lead to inflammatory diseases such as pulmonary fibrosis and cancer transformation.
In particular, p38 MAPK has a multifaceted role in CD4 T cells that have been implicated in initiating and driving sustained inflammation in autoimmune diseases, such as rheumatoid arthritis or systemic vasculitis.
Furthermore, alteration of miRNA expression in quiescent IBD tissues is consistent with the notion that genetic variants that result in differential gene expression (eg. that of regulatory molecules such as miRNAs) as well as mutations in the open reading frame are expected to contribute to multifaceted diseases.
Reptiles can spread diseases such as Salmonella.
