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Cancer is a multifaceted disease that represents one of the leading causes of mortality in developed countries.
Acute myocarditis (AM) is a "multifaceted disease" characterized by a large variety of acute manifestations, potentially followed by unpredictable sequelae ranging from dilated cardiomyopathy to recurrent arrhythmias [1, 2].
While Aβ and tau represent the two key pathological mediators of disease, other aspects of this multifaceted disease (e.g. oxidative stress, calcium-mediated toxicity, and neuroinflammation) are being unraveled, with the hope to develop a more comprehensive approach in exploring disease mechanisms.
As we study additional families and expand the phenotype of this multifaceted disease, we predict that patients/families will be identified in which seizures are an associated manifestation.
Psoriatic arthritis is a multifaceted disease.
Diabetes is a multifaceted disease and abnormalities include immune dysfunction and metabolic derangements, including hyperglycemia.
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Furthermore, alteration of miRNA expression in quiescent IBD tissues is consistent with the notion that genetic variants that result in differential gene expression (eg. that of regulatory molecules such as miRNAs) as well as mutations in the open reading frame are expected to contribute to multifaceted diseases.
Stroke and depression are complex and multifaceted diseases but both disorders have common pathological substrates that could be targeted by therapeutic intervention.
In summary we assembled a global pathway model for AKI based on proteomic changes, and further support the concept that the approach of in-depth Systems Biology coupled with high-resolution proteomic analysis represents a valuable approach to elucidate complex pathways and systems, especially in multifaceted diseases such as AKI.
Cancer is a multifaceted genetic disease caused primarily by environmental factors and its treatment is usually a combination of numerous varied modalities.
Sarcoidosis is a multifaceted granulomatous disease ranging from regressive localized forms to chronic systemic involvement.
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