However, the underlying mechanisms of PEI-induced multifaceted cell damage and death are largely unknown.
These data suggest that OXY induces a multifaceted cell starvation response, which ultimately induces programmed cell death.
In the last decade it has become clear that various complexes of the mitochondrial ETC have a multifaceted role in the execution of cell death.
In contrast, although proteasome inhibitor treatment has been associated with ER stress and the UPR, the specific contribution of proteasome inhibitors to ER stress-mediated cell death may be obscured by the multifaceted additional impact of these inhibitors on other regulatory pathways.
Altogether, adult neurogenesis is a complex process resulting from a fine balance between cell proliferation and cell death, migration, and differentiation and regulated by multifaceted molecular pathways.
9, 10 Further research of signaling pathways report the multifaceted actions of TNF-α in cancers, which lead to cell death, 11, 12 proliferation and migration.
Over the past few years, our view on the role of PKM2 in cancer progression has evolved from a strictly metabolic function to a more multifaceted role, which includes the regulation of cell proliferation and cell death through transcriptional regulation.
Clearly, further studies are warranted, adopting an integrated, multifaceted approach that takes into account the unique aspects of cell death regulation outlined above, in order to assess more accurately the impact that apoptosis has on endocrine responsiveness.
The multifaceted action of antimicrobial agents on cells, inhibiting growth and leading towards cell death, has been investigated extensively.
The multifaceted activities of XPO1 inhibitors may not only enhance p53-mediated MCL cell death but also delay or prevent the selection of p53 mutant subclones during therapy.
