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However, a multiethnic study on BC Malaysian demonstrated that the frequency of TP53 mutations is superior to BRCA1/2 genes alterations especially in patients with positive family history which could make BRCA1/2 mutation screening debatable [ 109].
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Heart Positive (Clinicaltrials.gov ID NCT00246376) was a large multiethnic study of healthy patients with HIV infection on stable HAART [ 13].
In this multiethnic study of prepubertal children, birthweight was associated with some risk markers for type 2 diabetes and CVD, although these were in most cases dependent on adjustment for childhood size (particularly height).
Despite this concern, the UKPDS outcome model has been applied in multiethnic study samples [ 28, 29].
The genetic heterogeneity in our multiethnic study population is a major concern.
One multiethnic study demonstrated that the risk in non-Hispanic whites and Hispanics differed with that in African Americans (10).
Overall, we show that there are substantial power gains to be had by focusing on large multiethnic studies.
The validity of available indicators of socioeconomic position is not yet established in multiethnic studies.
Unfortunately, other multiethnic studies have not considered differential sex effects across ethnic groups (10, 19, 20).
Large multiethnic studies with complementary individual- and area-level measures of SES are needed to corroborate our findings.
In one multiethnic cohort study, higher maternal education predicted later menarche, but income was unrelated (Windham et al. 2004).
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