Given the large and growing population affected by breast cancer worldwide and the important benefit of PA on breast cancer survival identified in observational studies, it is now necessary to study the impact of PA on disease-free survival and overall survival in a multicenter randomised study design.
This was a 12-week, Phase IIb, dose-ranging, double-blind, placebo (PBO) and active-controlled, multicenter, randomised study (NCT01242488), conducted between November 2010 and June 2012, to evaluate the efficacy and safety of subcutaneous OKZ in patients with moderately to severely active RA who had previously failed TNF inhibitor therapy.
Of note in this context, the initial decision 'no, in evaluation' for autologous haematopoietic stem cell transplantationin autoimmune disorders was crucial to obtaining research funds and did stimulate initiation of a multicenter prospective randomised study with an ultimately successful outcome.
We have performed a multicenter, double-blind, randomised study comparing the efficacy and safety of lithium gluconate with that of a placebo in helping to achieve a complete and lasting BZD withdrawal.
The NeuDia Trial is a national multicenter open controlled randomised study.
A recent multicenter, randomised phase II study, which compared the irinotecan/gemcitabine combination vs irinotecan in NSCLC patients pretreated with taxanes plus cisplatinum, demonstrated a poor antitumour activity of irinotecan (ORR=4.2%) (Georgoulias et al, 2004) as already reported by Negoro et al (see Ferrigno and Buccheri, 2000).
In this multicenter, randomised, double-masked, parallel study of 286 dry eye patients with fluorescein and rose bengal staining scores of ≥3 were randomised to the treatment groups in a 1 : 1 ratio.
Well-organised preclinical, clinical studies, especially multicenter, randomised clinical trials, although very challenging (Büchler et al. 2011; Ergina et al. 2009; Lyman et al. 2016) are extremely costly by all means.
This study is a multicenter randomised controlled trial with an economic evaluation alongside it.
This study is a multicenter randomised controlled trial in the Netherlands and inclusion started in July , 2009
The Celiac Disease and Diabetes- Dietary Intervention and Evaluation Trial (CD-DIET) study is a multicenter, randomised controlled trial to evaluate the efficacy and safety of a GFD in patients with type 1 diabetes with asymptomatic CD.
