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The multicenter neoadjuvant phase III GeparQuattro trial (NCT 00288002) recruited a total of 1,509 patients between August 2005 and November 2006.
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Two multicenter neoadjuvant studies (Remagus II and GeparQuattro) and two single center studies have used CellSearch® for CTC detection in early BC [4] [7].
Currently, the American College of Radiology Imaging Network is completing a multicenter neoadjuvant imaging trial that will evaluate the relationship between FLT uptake parameters and pathologic complete response of the primary tumor to neoadjuvant chemotherapy in patients with LABC [ 86].
Results from a multicenter Phase III study of neoadjuvant chemotherapy (FEC100) compared with hormone therapy (letrozole) are awaited (ClinicalTrials.gov identifier NCT00963729).
CHARISMA is a multicenter, randomized, phase III clinical trial.
This was a multicenter, open‐label, phase 2 trial.
This was a multicenter, blinded, Phase II study (NCT00880893) conducted in Singapore.
This multicenter, randomized phase III trial investigated the addition of oxaliplatin to multimodal treatment of LARC.
Clinical data were obtained from a multicenter, open‐label phase II study (NCT00244764).
Chi, K. N. et al. Multicenter phase II study of combined neoadjuvant docetaxel and hormone therapy before radical prostatectomy for patients with high risk localized prostate cancer.
The underlying hypothesis of this randomized, two-armed, open-label, multicenter, phase III trial is that neoadjuvant CRT increases the three-year overall survival by 12% compared to patients undergoing upfront surgery for resectable pancreatic cancer.
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