Consequently, this methodology will provide utility in future multi-arm multi-stage trials.
The FOCUS4 trial in CRC uses group-sequential multi-arm multi-stage methodology.
In 2011, Royston and colleagues proposed a particular class of multi-arm multi-stage (MAMS) designs intended to speed up the evaluation of new treatments in phase II and III clinical trials.
If the results of this trial are promising, the development pathway for this vaccine could include incorporating the FMP2.1 antigen as one component of a multi-stage, multi-antigen malaria vaccine in combination with RTS,S [8], improved adjuvant formulations [32] and/or separate development as a disease-blocking vaccine for use in targeted populations in malaria transmission areas.
If the results of these trials are promising, the development pathway for this vaccine could include incorporating the FMP2.1 antigen as one component of a multi-stage, multi-antigen malaria vaccine in combination with RTS,S [4], improved adjuvant formulations [34] and/or separate development as a disease-blocking vaccine for use in targeted populations in high malaria transmission areas.
Data collection was based on multi-stage, multi-cluster surveys of health facilities, clients and providers.
MAMS: Multi-arm multi-stage; TB: Tuberculosis; ESS: Expected sample size.
This is a pragmatic UK, multi-centre two-arm, randomised (1 1) controlled, multi-stage, open-label phase II/III trial in patients with inoperable locally advanced or metastatic clear cell renal cell cancer to evaluate the use of a sunitinib DFIS compared to the sunitinib CCS (see Figure 1).
This is a multi-stage, sub-maximal exercise test, modified from the Astrand-Ryhming protocol [ 51].
There are not enough hills in the Netherlands to make for interesting multi-stage racing.
