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Three types of project instigators are included – municipal, commercial and community – which have distinct decision heuristics and capabilities and follow a multi-stage development process.
This type of sandstone is characterized by small-scale single events, rapid lateral pinch outs and multi-stage development.
Submissions will be assessed again in March and successful entrants will be taken through the next steps of the multi-stage development process, including a pitch to the CBBC & BBC WW teams, culminating in the announcement of the project being taken forward to pilot stage around April/May 2016.
The pathogenesis of pancreatic ductal adenocarcinoma (PDAC) involves multi-stage development of molecular aberrations affecting signaling pathways that regulate cancer growth and progression.
Plasmodium parasites passage between the mosquito vector and human host to complete their multi-stage development, adopting multiple invasive 'zoite' forms throughout the process.
We have investigated the possibility that structural alterations of the 'nuclear' oncogene family (c-myc, N-myc, L-myc, fos, myb and p53) leading to aberrant expression might, as in several other tumour types, play a role in the multi-stage development of tumorigenesis in the human thyroid follicular cell.
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The unsteady RANS results indicate that multi-stage flame development, namely the initial expansion, flame brush development, its propagation and final stabilisation, is captured reasonably well in simulations.
This effusive phase completed the multi-stage volcano development.
If the results of these trials are promising, the development pathway for this vaccine could include incorporating the FMP2.1 antigen as one component of a multi-stage, multi-antigen malaria vaccine in combination with RTS,S [4], improved adjuvant formulations [34] and/or separate development as a disease-blocking vaccine for use in targeted populations in high malaria transmission areas.
If the results of this trial are promising, the development pathway for this vaccine could include incorporating the FMP2.1 antigen as one component of a multi-stage, multi-antigen malaria vaccine in combination with RTS,S [8], improved adjuvant formulations [32] and/or separate development as a disease-blocking vaccine for use in targeted populations in malaria transmission areas.
Our AMA-1-based malaria vaccine development strategy requires that two sequential milestones be accomplished prior to incorporation of one or more AMA-1 antigens into a multi-stage, multi-component vaccine [22].
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