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Translating this approach into treatment terms we can describe it as a multi-agent multi-target strategy.
We consider therapeutic actions as a combination of synergistic and/or antagonistic interactions in a multi-target strategy.
The simultaneous determination of the monoamines dopamine (DA), noradrenaline (NA) and serotonin (5-HT) in in vivo microdialysis samples remains challenging because of the low extracellular neurotransmitter levels in different brain regions, specific sample characteristics, and the quest for high temporal resolution and a multi-target strategy in neuropharmacological research.
This multi-target strategy conferred transgenic J. curcus plants with high resistance to multiple virus infection.
Our recent review [ 61] highlights convincing evidence from animal and human studies for the potential of prebiotics as a multi-target strategy to treat NAFLD.
Single modality of "One-molecule-one-target" strategy for treating AD has failed and so future therapies on "Combination-drugs-multi-targets" strategy (CDMT) will need to address multiple aspects to block the progression of pathogenesis of AD.
The complex etiology of Alzheimer's disease prompts scientists to develop multi-target strategies to combat causes and symptoms.
Finally, the success of multi-targeting strategy in the present study implied that multi-target drugs with rational design could be more promising in cancer therapy.
Finally, if the predictive signatures consist of a small set of proteins that implicate specific pathways (as implied by our work), this set of pathways becomes a prime target for a broad combinatorial multi-target drug strategy.
Nevertheless, here we provide evidences that the multi-target hpRNAi strategy can confer resistance to the ICMV.
As the future of breast cancer treatment lies in a combination of patient-tailored and multi-targeting strategies, we believe that TACAs - because of their profile of expression and their proaggressive function - will be considered potent molecular targets.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com