Translating this approach into treatment terms we can describe it as a multi-agent multi-target strategy.
Single modality of "One-molecule-one-target" strategy for treating AD has failed and so future therapies on "Combination-drugs-multi-targets" strategy (CDMT) will need to address multiple aspects to block the progression of pathogenesis of AD.
Permanent electrodes were implanted in both the STN and the GPi, bilaterally, according to our previous multi-target strategy.
Combining γ-secretase-modulation, PPARγ-agonism and inhibition of 5-lipoxygenase in one compound could be a novel disease-modifying multi-target-strategy for Alzheimer's disease to concurrently address the causative amyloid pathology and secondary pathologies like chronic brain inflammation.
e, Anatomical validation of optogenetic targeting strategy.
(A ) Tbx5 targeting strategy.
Nanomedicine products represent an opportunity to achieve sophisticated targeting strategies and multi-functionality.
A full understanding of these interactions is of paramount importance both when assigning the most beneficial treatment to patients and when designing new therapeutic strategies, such as combined modality treatments and multi-target or multiple-hit strategies.
We also thank the COST action CA15135 (Multi-Target Paradigm for Innovative Ligand Identification in the Drug Discovery Process, MuTaLig) for support.
Finally, an extension to multi-target scenarios will also be considered.
Multi-target directional drilling was used for remaining oil development at fault edges.
