The combination drugs currently employed are primarily of rational design, but the increased efficacy they provide justifies in vitro discovery efforts for identifying novel multi-target mechanisms.
These compounds were suggested to exert their anticancer activity through a multi-target mechanism based on their structural features.
Additionally, the results demonstrated the promising activity of these compounds with a multi-target mechanism as good candidates for further development into potential anticancer agents.
The formulas act according to a multi-target mechanism on different pathogenic factors of atherosclerosis [ 11].
Inhibition of PTEN partially reversed mastic oil effects on tumor cell growth, indicating a multi-target mechanism of action.
In this paper, a novel approach of global chemomics integrated systems biology was established to define the multi-component and multi-target mechanism of action of the CBPP dropping pill.
These data suggest that the multi-target mechanism of low-dose prednisolone and dipyridamole creates a dissociated activity profile with an increased therapeutic window through cellular network selective amplification of glucocorticoid-mediated anti-inflammatory signaling.
These results suggest that cellular network selective amplification of glucocorticoid activity by the multi-target mechanism of low-dose prednisolone and dipyridamole may provide a solution to the challenging problem of dissociating glucocorticoid-induced HPA axis suppression.
We therefore propose that a multi-tiered targeting mechanism, utilizing both global and specific features of tubular organs, achieves a distinct localization pattern of Dia, thereby enabling execution of the cardinal process of apical secretion in these organs.
In terms of mechanism of action, sorafenib is reported to inhibit tumor growth via multi targets, acting directly on the tumor and/or on tumor angiogenesis (through inhibition of VEGFR and PDGFR signaling) [4, 5].
Several targeting mechanisms are conceivable.
