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Gupta et. al [ 4] reported on a multi-step trial of a deidentification software engine and by the third round, only 8 reports out of 300 had organizational or personal names or accession numbers missed.
NordLOTS is a multi-national, multi-step trial designed in part to evaluate the relative efficacy of continued CBT or switch to SRT among children and adolescents with OCD who were rated as non-responders to an initial course of individual CBT [ 18, 45].
This was previously a multi step process.
The methodology is illustrated with data from the STAR*D trial, a multi-step randomized study of treatment alternatives for individuals with treatment-resistant major depressive disorder.
To deal with these challenges, the British Medical Research Council has developed a framework for evaluating complex interventions [9] that suggests a multi-step approach including a development phase, feasibility/piloting, evaluation (preferably through a randomised controlled trial) and implementation.
They suggest a multi-step approach, including a development phase, followed by feasibility/piloting, evaluation (preferably through a randomised controlled trial) and implementation.
Within our two sequential randomized mail and telephone trials of contact strategies, conducted from June to December 2012, eligible subjects were contacted using a multi-step, structured protocol starting with mailed letters and then telephone calls, as needed for non-responders to mailings.
It was a technical, multi-step hassle.
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