Synthesis of these compounds was carried out via a multi-step sequence consisting of copper-catalyzed azide alkyne cycloaddition (CuAAC) as a key step in aqueous media.
These compounds were synthesized via a multi-step sequence consisting of copper-catalyzed azide-alkyne cycloaddition (CuAAC) as a key step in aqueous media.
Elegant synthesis of these compounds was performed via a multi-step sequence consisting of MCR, Sandmeyer type iodination, Sonogashira type coupling followed by iodocyclization and then Pd-mediated various C C bond forming reactions.
Expeditious synthesis of these compounds was carried out via a multi-step sequence consisting of few steps such as Gewald reaction, Sandmeyer type iodination, Sonogashira type coupling followed by iodocyclization and then Pd-mediated various C C bond forming reactions.
Oesophageal adenocarcinoma usually arises through a multi-step sequence from Barrett's metaplasia to dysplasia and carcinoma [14].
Esophageal adenocarcinoma development experiences a long procedure through a multi-step sequence of metaplasia-dysplasia-adenocarcinoma.
The classic sigmoidal dose response of steroid-regulated gene products belies the complexity of a system which relies on an intricate, multi-step sequence of events to initiate transcription from a target gene (McKenna et al., 2009).
For instance, the retention duration of a multi-step sequence (remove the mitten from the puppet's hand, shake the mitten, replace the mitten; see Fig. 5) can be increased by manipulating a number of factors.
Correa proposed that the intestinal-type gastric cancer sequentially transformed from normal mucosa into atrophic gastritis, intestinal metaplasia, dysplasia and finally to invasive adenocarcinoma in a very similar fashion to the multi-step sequence of events from precancerous changes to invasive disease in colorectal cancer (Correa, 1988).
This streamlines the synthesis and increases the efficiency considerably, because pre-functionalization (often achieved within multi-step sequences) of substrate(s) is no longer required.
We propose a supervised approach to learn what we refer to as ' multi step reaction sequence likeness', i.e. whether a compound compound pair is possibly converted to each other by multiple enzymatic reactions, as an extension of the previous work (Kotera et al., 2013b).
