Altogether, this multi-step screening process may significantly improve clinical outcomes of cell-based therapies.
The multi-step screening process needs to be designed, performed and evaluated carefully, since the decisions made based on the screening may have consequences on the whole lifecycle of a pharmaceutical product.
The multi-step screening protocol was applied on a proprietary compound collection and a diverse commercial compound collection.
RvdL selected articles through a multi-step screening process first based upon the assessment of the title and the abstract, followed by assessment of the article content.
Single nucleotide polymorphisms (SNPs) in seven loci were selected for follow-up in a large independent cohort of 538 SLE patients and 522 controls using a multi-step screening approach based on novel metrics and expert database review.
The size of the GWAS study did not allow for rigorous exclusion of false positives, so we used a multi-step screening algorithm which included novel metrics derived from the GWAS chip data and expert literature and database review to increase the likelihood of selecting true positive SNPs for validation.
The multi-step screen involves a first round using a 2-dimensional, cell-line-based scrape-healing assay, then a second round using a 3-dimensional tubulogenesis assay; both of these rounds use new cell lines described in this report.
Here we describe our methodology of multi-step mAb screening focused on identifying mAbs exhibiting efficacy and specificity in labeling mammalian brain samples.
In the present study, we have utilized a multi-step virtual screening protocol to identify inhibitors of DNMT1, which offers a starting point to develop more potent DNMT1 inhibitors as anti-cancer agents.
In this study, we developed a multi-step biomedical informatics screening (MSBIS) approach leveraging publicly available bioactivity and drug safety data to identify concomitant drugs that mitigate the risks of MCP-induced TD.
This was previously a multi step process.
