As automated multi-step genome wide analyses can sometimes introduce biases and misinterpretations, we took the maximum of precautions at each step.
We have developed a multi-step viral genome assembly pipeline named VirAmp, which combines existing tools and techniques and presents them to end users via a web-enabled Galaxy interface.
This was previously a multi step process.
A multi-step gene expression profiling study was conducted.
A simulation study by Vitezica et al. [ 16] compared five BLUP methods and investigated the effect of selection and genome-wide evaluation methods (one-step and multi-step) on bias and accuracy of genomic predictions.
The annotation of the genome was refined in a multi-step approach, including modern bioinformatic pipelines, transcriptome and proteome data.
To test for phylogenetic autocorrelation and to correct for phylogenetically-based non-independence of genome-size data, we used the multi-step approach of Abouheif [ 49].
While the multi-step model of pediatric leukemogenesis suggests interplay between constitutional and somatic genomes, the role of inherited genetic variability remains largely undescribed.
In the first genome projects, the process of obtaining the DNA sequence by multi-step clone-by-clone sequencing approaches was costly and tedious.
It is now widely accepted that cancer is a multi-step process resulting from the accumulation of both genetic and epigenetic alterations of the genome.
Since carcinogenesis is a long-term, multi-step process and involves multiple genes, it is of critical importance to study the chronic exposure and genome-wide expression changes to define the underlying molecular mechanisms of carcinogenesis, which is largely unknown.
