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For coding variants, the probe with the higher p-convert value was chosen based on this classification, whereas for all remaining variants probe sets were further filtered according to the following multi step approach.
But the advantage of this model over the standard mapping and multi-step approaches previously proposed is that individual loci are automatically mapped in a single step by simultaneously considering all available evidence.
Despite this, there is still a lack a publicly available and easy-to-use resources dedicated to the study of retrocopies (Kaessmann et al., 2009), making it necessary either to use manual and multi-step approaches to explore retrocopies or to use non-specialized databases, such as the pseudogene databases (e.g. http://www.pseudogene.org/), that contain only basic and/or restricted information.
The paper presents a new multi-step approach aiming at source identification and release history estimation.
An alternative multi-step approach for the structural analysis of larger VLFS has also been outlined.
The multi-step approach for analytically validating the performance of this system is presented.
The application of the multi-step approach enabled a significant increase in the knowledge of contamination at the site.
The multi-step approach has proven to be effective and may be applied to other complicated contamination cases.
The annotation of the genome was refined in a multi-step approach, including modern bioinformatic pipelines, transcriptome and proteome data.
For each continent, the overall combinations of covariates and model types were explored using a multi-step approach to identify the model with the greatest predictive power in countries for which migration data were not available.
The multi-step approach employed in this work involves the use of the density functional theory (DFT), semiempirical (ZINDO) and Monte Carlo (MC) theoretical methods.
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