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In a transgenic mouse model of multi-stage pancreatic neuroendocrine carcinogenesis (PNET), RIP-Tag2, expression of the SV-40 T-antigen (Tag) in pancreatic β cells leads to inhibition of the tumor suppressors p53 and Rb, promoting a temporally defined yet stochastic multi-stage pathway to tumorigenesis.
Desalination is a multi-stage, multi-pathway process, involving catalytic adsorption and desorption (Antia 2015a, b, 2016a, 2017, 2018a).
A multi stage sampling technique was employed.
A multi stage cluster sampling was applied.
Based on the above biological studies, in this paper we thus postulate that the incidence data of human colon cancer are described and generated by a multi-stage model involving 2 pathways as defined above.
For developing efficient prevention and controlling procedures for human colon cancer and for prediction of future human colon cancer, in this paper we have developed a stochastic model and a state space model for carcinogenesis of human colon cancer involving multiple pathways with each pathway being a multi-stage model.
The pathogenesis of pancreatic ductal adenocarcinoma (PDAC) involves multi-stage development of molecular aberrations affecting signaling pathways that regulate cancer growth and progression.
If the results of these trials are promising, the development pathway for this vaccine could include incorporating the FMP2.1 antigen as one component of a multi-stage, multi-antigen malaria vaccine in combination with RTS,S [4], improved adjuvant formulations [34] and/or separate development as a disease-blocking vaccine for use in targeted populations in high malaria transmission areas.
If the results of this trial are promising, the development pathway for this vaccine could include incorporating the FMP2.1 antigen as one component of a multi-stage, multi-antigen malaria vaccine in combination with RTS,S [8], improved adjuvant formulations [32] and/or separate development as a disease-blocking vaccine for use in targeted populations in malaria transmission areas.
The characterization of the six BnFT paralogues in B. napus increases our understanding of Brassica genome evolutionary pathways involving genome triplication via multi-stage processes.
In the future, we plan to improve the model by adding multi-stage amplification that takes advantage of polarized synthesis and endocytosis of the pathway components.
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