It was recently found that p62 functioned as a multi-functional protein at a critical decision point to control cell death or survival.
Presently, it is unclear whether all these reported activities reflect splicing dependent or independent functions and whether Prp19 might be a multi-functional protein that interacts with distinct groups of proteins to carry out different functions.
E6-mediated p53 degradation has been considered a hallmark function of oncogenic HPVs, although E6 is a highly multi-functional protein [7], [8].
Neurofibromatosis type I (NF1) is an autosomal dominant disorder associated with loss-of-function mutations in the NF1 tumour suppressor gene that encodes the multi-functional protein Neurofibromin (Wallace et al, 1990; Xu et al, 1990; Roth et al, 2008a; Gottfried et al, 2010).
Han, J. M., Heejoon, M. & Kim, S. Antitumour activity and pharmacokinetic properties of ARS-interacting multi-functional protein 1 (AIMP1/p43).
Akt1 is a multi-functional protein, implicated in multiple human solid tumors.
They now have a set of bacterial superglues, to build multi-functional protein teams and tune surface receptor signalling on cancer cells and immune cells.
We did not observe similar results for either of the mutants, and we postulate that this may have some functional relevance, as PNF1 is a multi-functional protein that interacts with several ligands.
Akt1 is a multi-functional protein implicated in key cellular processes including regulation of proliferation, survival, metabolism and protein synthesis.
