We speculate that such HER2 overexpression, in compensation with downregulated EGFR, has a role in the activation of Akt/GSK-3 β/snail pathway, although HER2 inhibitors such as lapatinib did not exhibit significant inhibitory effect on EMT unlike PI3K inhibitor, probably due to its multi functional effects on the various signalling pathways (Supplementary Figure 4S).
The underlying reason could be the tight linkage of two agronomically important genes and/or pleotropic (multi-functional) effect of ABI3VP1 TF gene on seed weight and pod number regulation at this target QTL interval.
Evidence for such multi-functional effects from agroforestry dedicated to bioenergy is, however, still scarce [74].
The nickel possesses multi-functional effects during the synthesis process as carbon catalyst (Ni II)), molecule binder (NiTi) and pseudo-capacitance supplier (NiOx).
Glycogen synthase kinase-3β elicits multi-functional effects on intracellular signaling pathways, thereby making the kinase a therapeutic target in multiple pathologies.
However, W1087 was selected by the multi-locus mixed-model analysis to explain part of flowering time variation together with Ins883 suggesting a possible functional effect of this SNP in this trait.
Turned a washing machine drum into a coffee table using toughened frosted glass, castors and multi functional LED's.
Hand4help Hand4help is developing low-cost, multi functional, 3D-printed robotic hand prosthesis for amputees.
She leads a multi functional life and the clothing she wears should reflect that.
This makes sense as most effectors are multi-functional and have subtle effects on the host cell, which if left unchecked may become too deleterious, loosening the pathogen's grip on the host cell.
What we demonstrated here is the effect of multi-functional enzyme partition under increasing substrate condition on preventing over-production and maintaining homeostasis of an amino acid.
