Compound 3a is a promising candidate for further development of novel multi-functional agents in the therapy of AD.
A novel series of donepezil based multi-functional agents "(E -5,6-dimethoxy-2- 4- 4-substituted pipE -5,6-dimethoxy-2- 4- 4-substituted-1H-indE -5,6-dimethoxy-2- 4- 4-substitutednthE -5,6-dimethoxy-2- 4- 4-substituted agE -5,6-dimethoxy-2- 4- 4-substituted
Among the entire series compounds IP-9, IP-13 and IP-15 appeared as most active multi-functional agents and displayed marked AChE inhibitory, Aβ disaggregation and antioxidant activity.
Thus, the present study evidently showed that IP-9, IP-13 and IP-15 are potent multi-functional agents against Alzheimer's disease and might serve as promising lead candidates for anti-Alzheimer drug development.
We explored and compared in this study various synthetic routes for preparing a number of C-7α-substituted derivatives of E2, which are highly useful for the design and synthesis of high-affinity ER antagonists, ER-based imaging ligands, and other ER-based multi-functional agents.
These diverse properties highlight the potential of the lead ligand, PBPT, as a promising multi-functional agent for AD treatment.
In addition, compound 5j exhibited higher self-induced Aβ aggregation inhibitory activity than curcumin, which could become a multi-functional agent for further development for the treatment of AD.
This work provides a new and efficient approach to evolve novel multi-functional antiviral agents by rational integration and optimization of previously reported antiviral agents.
Especially, the compounds 4c and 4d also exhibited high antiviral activities, which provide a new and efficient approach to evolve novel multi-functional antiviral agents by rational integration of active pharmacophores.
Moreover, as Gd 2O 3 nanoparticles are already used as MRI multi-functional contrast agents, their use for THz studies might enable the combination of the two imaging modalities (MRI-THz) and the combination and enhancement of the offered information.
To develop a multi-agent-based scheduling system for Intelligent Manufacturing, it is necessary to build various functional agents for all the resources and an agent manager to improve the scheduling agility.
