A series of new 4-aza-podophyllotoxin analogs containing thiazole unit were synthesized via multi-component reactions of aldehydes, tetronic acid and 2-methylbenzo[d]thiazol-5-amine under microwave irradiation.
Multi-step reactions and multi-component reactions (MCRs) enable a bottom-up approach with biocatalytic reactions working together in one compartment and recations hindering each other within different compartments or steps.
2-amino benzo[h]chromene are some examples of multi-component reactions.
In recent years, considerable attention has been devoted to multi-component reactions (MCRs) due to their widespread applications in organic, medicinal and green chemistry.
Multi-component reactions are powerful tools in the efficient and rapid generation of diverse libraries of compounds, and are particularly useful for high-throughput screening.
The huge interest for such multi-component reactions during the last years has been oriented towards developing combinatorial chemistry procedures, because of their high efficiency and convenience of these reactions in comparison with multistage procedures.
Multi-component reactions (MCR) are one-pot processes with at least three components to form a single product, which incorporates most or even all of the starting materials [1 6].
In our continued interest [30, 37 47] in the development of highly expedient methods for the synthesis of diverse heterocyclic compounds of biological importance via one-pot multi-component reactions (MCRs) and avoiding organic solvents during the reactions in organic synthesis leads to efficient, environmentally benign reagents, clean, and economical technology (Green Chemistry Concepts).
In addition to the intrinsic atom economy and selectivity underlying such reactions, time and energy saving, as well as environmental friendliness, have led to significant efforts to design and implement multi-component reactions both in academia and industry [2, 3, 4, 5].
Structure-based design of libraries of multi-component reaction products yields novel potent anti-tuberculosis compounds.
All these compounds were prepared via a multi-component reaction (MCR) involving sequential I2-mediated Biginelli reaction followed by Cu-free Sonogashira coupling.
