Several large multi-centre genome wide association studies have reported high incidences of GBA mutations in sporadic PD (Sidransky, 2005; Mata et al., 2008; Mitsui et al., 2009; Sidransky et al., 2009a, b; Sidransky and Lopez, 2012).
May involve estimation, hypothesis generation or hypothesis testing/confirmation. Can be small (e.g., within a single lab) or large scale (e.g., multi-centre genome-wide association studies).
Of the 11 RCTs, 1 was multi-national, 7 multi centre, and 3 single centre studies.
Of the 7 non RCTs, 1 was multi-national, 2 were multi centre, and 4 single centre.
We have witnessed a shift towards these so-called whole genome association studies, where large multi-centre consortia attempt to examine a very large number of cases and controls for a particular disease.
The genome of L. major Friedlin, the reference strain (MHOM/IL/80/Friedlin, zymodeme MON-103), was sequenced as part of a multi-centre collaboration (Sanger Institute/EULEISH, Seattle Biomedical Research Institute, FMRP).
A multi-centre, larger-scale investigation is urgently needed".
Cross-sectional multi-centre study.
Design: multi-centre prospective randomised trial.
Methods: This is a retrospective, multi-centre observational study.
An economic evaluation was conducted within a multi-centre trial.
