We acknowledge that multi-center genome-wide association studies on cardiovascular disease and diabetes include very large cohorts; however, our approach was designed to better understand disease biology by identifying heritable traits that influence gene expression, not to identify genetic markers solely based on their predictive power of a disease state.
More recently, a multi-center genome-wide association study (GWAS) has identified the thymic stromal lymphopoietin (TSLP) gene, at 5q22, as an important candidate gene in the pathogenesis of the disease [ 11].
Three multi-center genome-wide transcriptomic data sets (Affymetrix HG-U133 A/B) from a total of 79 individuals, including 20 healthy controls (control group - CG), as well as 26 osteoarthritis (OA) and 33 RA patients, were used to infer rule-based classifiers to discriminate the disease groups.
The EuroBCM study in PD was a cross sectional, observational, multi center trial in 28 centers in 6 European countries.
The multi center, cross-sectional study of patients with SCI was conducted in 14 countries.
This multi center trial is based on a non-blinded randomized controlled study design.
A genome wide association scan (GWAS) conducted by multi centers identified a susceptible locus (15q25) for lung cancer [23] which accounts only for 4% of lung cancer risk.
Despite this ambitious and multi-center approach, no SNPs reached genome-wide significance (Becker et al. 2014) and no single SNPs were associated with DD in samples from more than one population.
A large international multi-center linkage study of 149 breast cancer families identified the chromosome 4 region as the best linkage across the genome (LOD=1.8) [ 19].
We filled this gap with a multi-center study of the geographical and demographic distribution of genotypes, subtypes and mutations in the S region of the HBV genome in donors from five blood centers, where the blood donors were geographically, socially, economically and ethnically diverse.
Multi-center retrospective review.
