For the limitations in this study, to drawn more solid conclusions, further large, randomized, multi-center, and long-term follow-up trials were required.
For operable patients, prospective multi-center and cooperative groups trials of SABR are ongoing or completed, and international randomized trials of SABR vs. surgery have been initiated.
Clinical, multi-center and adequately controlled outcome studies of high quality should also accompany the imminent introduction of LiTT into the field of epilepsy surgery and therewith permit critical scientific evaluation and rational, individual, clinical decisions.
The main strengths of the current study include its large scale, the multi-center and prospective properties and the full capture of common genetic variation in the candidate genes.
Prospective, multi-center and multinational study.
Prospective, randomized, multi-center and multinational study.
To test this idea, additional large cohort, multi-center and prospective clinical trials are needed.
Health-care-funded research was less frequently multi-center, and when it was, it was mainly domestic to Finland.
Therefore, a scientific design using a multi-center and random sampling method with larger sample size could be used to better explore this comorbidity.
Researchers have implicated the increased complexity of research (including technological advances) and the increase in multi-center and multidisciplinary research collaborations to the growth in the number of authors per manuscript.
To obtain more robust evidence, large cohort, multi-center and prospective clinical trials should be designed in the near future, in which therapeutic decisions are based on HER2 analyses of both tumor tissue and CTCs.
