In the multi-agent group, 77 (10%) of 779 patients conceived early, two then relapsed.
Patients in the multi-agent group had a significantly higher number of spontaneous miscarriages than those receiving single agent treatment.
Of these, 34 were from the single-agent and 44 from the multi-agent group (Table 2-wrap>).
On comparing both groups there was a significantly higher incidence of terminations and miscarriages in the multi-agent group (Table 2).
Of the 230 patients who became pregnant, three patients within the single agent and two within the multi-agent group relapsed.
Early pregnancies were more common in the single agent group (P<0.001), but spontaneous miscarriages and terminations were more likely to occur in the multi-agent group (P=0.04 and 0.03, respectively).
Consequently, though patients in the multi-agent group appeared to be at greater risk of miscarriage (18%) than those in the single agent group (8%), it is unlikely that they are at greater risk than that of the general population.
Though in both treatment groups, more pregnancies occurred in the later 6 months of the follow-up period, this was especially significant in the multi-agent group with 25 out of 77 patients conceiving before 6 months and 52 out of 77 after 6 months (P=0.008).
The multi agent programming language is a foundation for developing multi agent applications and carrying out multi agent simulations.
Most relapses occurred within the first 12 months (65% in the single-agent and 82% in the multi-agent treatment groups).
This study aimed to investigate the safety of early conception following chemotherapy for GTT in the single and multi-agent treatment groups.
