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Current treatment of osteosarcoma consists of multi agent chemotherapy and surgical resection[ 3].
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A high research priority is to identify those ER-positive patients who will benefit from multi-agent chemotherapy.
It is possible that these impairments are a consequence of intensive multi-agent chemotherapy and cranial irradiation.
A retrospective series from Memorial Sloane Kettering Cancer Centre reviewed 66 patients treated with debulking surgery, multi-agent chemotherapy and abdominopelvic radiotherapy.
Through its ability to inhibit caspases, overexpression of XIAP renders cells resistant to multi-agent chemotherapy.
Three deleted cases were exposed to multi-agent chemotherapy with alkylating agents.
Recent studies confirmed that overexpression of XIAP confers resistance to multi-agent chemotherapy, including stimuli of the mitochondrial and death receptor pathways of caspase activation [9] [11].
All patients (excepted three who had received radiotherapy alone) had been treated with multi-agent chemotherapy (AA and ATII) combined or not with radiotherapy.
Many reports in cultured cells have demonstrated that overexpression of XIAP confers resistance to multi-agent chemotherapy, including stimuli of the mitochondrial and death receptor pathways of caspase activation [9] [11].
They received PVACEBOP multi-agent chemotherapy as primary therapy.
There were fewer early pregnancies in the women who had received multi-agent chemotherapy.
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CEO of Professional Science Editing for Scientists @ prosciediting.com