The results showed that LGG partially prevented or treated the unwanted adverse effects of DON/ZEA in mice by regulation of goblet cell mucus secretion, improvement of plasma d-lactate, IL-8/CXCL8 and serum Ig levels.
In addition, several mediators secreted from eosinophils and lymphocytes can amplify portions of the inflammatory cascade; they can increase airway hyperresponsiveness, inflammatory cell accumulation, and stimulate mucus secretion, both of which can contribute to airway obstruction and remodeling [ 33].
The depletion of mucus secretion is one of the pathogenic mechanisms accountable for gastric mucosal erosions [ 34].
Decreased numbers of goblet cells, reduced mucus secretion and abnormalities of its composition are well described in a number of intestinal disorders [ 52- 54].
The infiltration of leukocytes and mucus secretion are indexes of AR.
Mucociliary transport (MCT) velocity is determined by several factors, such as ciliary beat frequency (CBF), rate of mucus secretion and rheological properties of mucus.
Our lung tissue model displays a stratified epithelium supported by a fibroblast layer and is capable of mucus secretion and active formation of extracellular matrix proteins (supplementary material Fig. S3) (Nguyen Hoang et al., 2012).
Consequently, the role of the test samples in increasing mucus secretion, and expression of epidermal growth factor (EGF), as well as elevating PGE2 synthesis were also investigated.
Further analysis of these 121 differentially expressed genes has identified two main functions: xenobiotic metabolism and nucleotide metabolism (representing 33% of the reversible gene expression changes) (Table 2) and airway mucus secretion (representing 12% of the reversible gene expression changes) (Table 3).
TGF-α in microemulsion formulation was more effective than TGF-α in solution formulation in the increase of gastric mucus secretion, in the decrease of gastric acid secretions and ulcer scores.
