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Highly viscous mucus poses a big challenge for the delivery of particulates carrying therapeutics to patients with cystic fibrosis.
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The mucus can entrap nanoparticles (and thus reduce their translocation) because it poses a physical barrier due to its thickness, density, negative charge, and constant renewal (Cone 2009; Crater and Carrier 2010; Szentkuti and Lorenz 1995).
This poses a puzzle.
Which poses a puzzle.
This poses a serious problem.
Medicare poses a larger quandary.
Europe poses a bigger threat.
This poses a delicate problem.
This poses a regulatory risk.
This poses a major challenge.
Bahrain poses a different problem.
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