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Airway mucus plays a vital role in the constant clearance of inhaled pathogens and particulates.
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The association of Akkermansia muciniphila, a mucin-degrading bacteria residing in the mucus layer, in conditions of obesity and systemic insulin resistance, further supports the hypothesis that the mucin-dependent mucus layer plays a key role in intestinal dysregulation [ 30].
Mucus rheology plays a critical role in maintaining respiratory health.
The intestinal mucus layer plays a key role in the maintenance of host-microbiota homeostasis.
Release of preformed mucus also plays a role in promoting epithelial recovery after acute injury by forming a mucoid cap beneath which re-epithelization occurs.
Mucus clearance plays an important role in innate immunity in the mammalian lung [ 74].
The possible presence of a surfactant factor both within and between the sol and gel phase of the mucus may play a role in facilitating mucus clearability or cough clearability, by allowing the mucus layer to slide easily and more effectively on top of the cilia.
The mucus layer is not impenetrable, however, and the tight junction complexes between the epithelial cells below the mucus layer play a crucial role in providing a second level of protection.
Prostaglandins promote the secretion of mucus and play a role of protection of the gastric mucosa.
Lactoferrin, an iron-binding glycoprotein found in cervical mucus and amniotic fluid, plays a defensive role against mucosal infections.
The presence of mucus in gastric mucosa play an important role as a diffusion barrier and lubrication to protect the stomach from harmful agents, suppress the growth of microorganisms and facilitate the movement of food through the gastrointestinal tract [ 23].
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