Exact(2)
These include the susceptibility to digestive enzyme degradation, instability in the acidic pH environment, poor mucus diffusion and inadequate permeation through the gastrointestinal epithelium.
Furthermore, the influence of enzymatic degradation on charge distribution of the polymer as well as on mucus diffusion and mucoadhesion was investigated.
Similar(58)
Interactions with mucus components were determined within mucus diffusion studies and rheological investigations.
In this design process, mucus diffusion studies are mandatory and have an important role in the selection of the best drug candidates.
Herein, PEG-Ptyr showed a 3-fold lower mucus diffusion, after incubation with IAP.
Transient interaction of PEGylated dendrimers with cellular junctions of the polarized epithelium as probed by a reduction in transepithelial electrical resistance, faster mucus diffusion, along with reduced cellular internalization compared to the non-PEGylated counterpart promotes transport across the epithelial barrier.
These NPs might lead to drug entrapment within mucus, impedance of proper mucus dispersion, and transportability.
Alginate freely diffused into mucus and reduced diffusion of 500 nm beads.
Second, the NA protein is able to cleave sialic acid residues in mucus and cellular glycocalyx, a process that is believed to facilitate diffusion and dissemination of the virus within the respiratory tract, giving influenza virions larger access to target cells of the airway epithelium [11].
Diffusion and resistivity.
Diffusion and ion implantation.
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