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Other factors accounting for the inconclusive results included high IFN-γ readouts in the negative control well and high background discoloration of the wells likely related to the high protein and mucus content of induced sputum.
Mucus content of rats' colon in AA group was significantly (P <0.01) reduced compared to controls.
In these samples the mucus content of the colonic goblet cells leads to a non-specific immunoreactivity.
The mucus content of gastric mucosa in rats treated with ethanol (ulcer control group) was significantly reduced when compared to positive control or the extract groups.
The gastroprotective effects of HPTP could be attributed to increase in pH and mucus content of gastric content, increase endogenous enzymes and PGE2, and decrease in MDA level in gastric homogenate, over-expresion of HSP70 and TGF-β proteins, and down-expression of Bax protein.
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The present study showed increased levels of MDA and decreased level of mucus contents of gastric mucosa in the ulcer control group.
4, 5 In addition, downregulation of the adhesion molecules E-cadherin and β-catenin may lead to reduced cell adhesion in areas of high mucus content and promote scattering of tumor cells, further leading to advanced tumor stages and poorer prognosis.
The mechanisms of EtOH-induced acute gastric mucosal injury are thought to arise as a result of depletion of gastric mucus content, damaged mucosal blood flow, haemorrhage and necrotic of mucosal tissues and over production of free radicals which lead to an increased lipid peroxidation [ 45].
Pre-treatment of rats with CPRHE significantly replenished the depletion of mucus content caused by ethanol administration and decreased the acidity of gastric walls.
The replenishment of the loss in mucus content by CPRHE was evidenced by the stumpy amount of magenta color in the histological analysis as compared to the control group.
In particular, local invasiveness may be increased in areas of high extracellular mucus content, as it is found in MAC.
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