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These data reveal a requirement for core 3-derived O-glycans in colon mucus barrier function.
Cisplatin appears to alter the mucus barrier function in the intestinal mucosa.
First, alteration of the mucus barrier function is a cause of cisplatin-induced mucositis.
However, mucus thickness alone was not a useful indicator of mucus barrier function since, for example, the IL-10-deficient mice had a thicker inner attached mucus layer.
Yet altering the physical properties of mucus while not respecting the effects on mucus barrier function and aerosolizability of expectorated secretions could lead to problems for both the patient and the surrounding community.
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Intestinal homeostasis depends in part on the equilibrium between absorption (nutrients, Na+ ions), secretion (chloride ions, IgA, mucus, cytokines) and barrier function of the digestive epithelium.
Our observations suggest that the inner mucus and its barrier function is an important factor in limiting bacterial contact with the epithelium and that defects in this system might trigger inflammation.
Epithelial cells protect the intestine through different mechanisms such as barrier function, mucus secretion, antibacterial peptide synthesis, cytokine and chemokine secretions [19].
IEC represent a relevant model to study yeast probiotic effects in the intestinal tract because IEC are involved in several mechanisms allowing protection such as barrier function, mucus layer protection, antibacterial peptide secretion and cytokine and chemokine secretion [19].
The novel treatment of modified release PC was based on the observation that specifically patients with UC had a low intrinsic mucus PC content that reduces the hydrophobic barrier function of the intestinal mucus (10, 11).
Assuming that the inner mucus layer of the colon is vitally important for colon barrier function, a thinner mucus layer could be associated with inflammation.
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