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This data also revealed that mucosal uptake of recombinant fowl pox (rFPV) was far superior to plasmid DNA.
Additionally, intestinal barrier function was severely affected as evidenced by a strong increase in the mucosal uptake of Evans blue in vivo.
HIV itself may result in an up-regulation of cytokines and hepcidin causing anaemia through inhibition of mucosal uptake of dietary iron and sequestration of iron in bone marrow macrophages [ 18].
Similar(57)
Otherwise, the various and diverse methods which have been used to measure bioavailability measure different variants of true or net intestinal or mucosal uptake and transfer of a nutrient and do not consider the further systemic metabolism, excretion and utilization of the dietary component.
Our findings have, at least, contributed to exclude CFTR as a causative factor for defective mucosal uptake and intracellular transport of long-chain FA as well as impaired intra-enterocyte handling of lipids.
Literature suggests that positive surface charge enhances mucosal uptake due to anionic nature of mucous layer [18].
As reported in the literature, positive surface charge could enhance the mucosal uptake due to anionic nature of mucous layer [37].
The enhanced immunogenicity and immunoprotection were associated with the M cell-targeting ability of CPE30-CS-pVP1 which improved its mucosal uptake and transcytosis.
Mucosal uptake will also occur.
However, on the positive side, it has been demonstrated that saponins affect nutrient uptake through the intestinal membrane, by increasing the permeability of intestinal mucosal cells in vitro, inhibiting active mucosal transport and facilitating uptake of substances that are normally not absorbed [ 21].
Besides, stem cells generate less documented microfold cells (M-cells) responsible for the uptake of mucosal antigens [ 33] and the recently described tuft cells secreting endogenous intestinal opioids [ 34].
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